For instance, several of them have been identified in previous obesity studies including ACACB, ACSS, ADIPOQ, DGAT2, HSL, FASN, PNPLA2, PNPLA3, PPAR-γ, SREBP1 SNP17 and TNF [25–37]. This evidence concerns the gene ACACB and obesity due to melanocortin 4 receptor deficiency.