For instance, several of them have been identified in previous obesity studies including ACACB, ACSS, ADIPOQ, DGAT2, HSL, FASN, PNPLA2, PNPLA3, PPAR-γ, SREBP1 SNP17 and TNF [25–37]. The gene discussed is PNPLA3; the disease is obesity due to melanocortin 4 receptor deficiency.