We used the NUP98-HOXD13 (NHD13) transgenic model of MDS, which we and others have shown is highly penetrant and recapitulates the key features of human MDS, including peripheral blood cytopenias, dysplasia, ineffective hematopoiesis, and transformation to AML [22, 33]. This evidence concerns the gene NUP98 and myelodysplastic syndrome.