TSLP and allergic disease: In our barrier-injury model, FAIRE identified several dynamic chromatin peaks within the TSLP TAD; Epidermal and 3D peaks could represent enhancers that are necessary for sfTSLP and/or TSLP transcription, and Barrier-deficient peaks may be responding to the sensor that detects epidermal barrier breach and induces TSLP. Two Barrier-deficient peaks were identified near the TSLP promoter, both of which overlapped allergy associated SNPs (rs17551370 [42] and rs2289277 [44, 45]); the latter is also an established expression quantitative trait locus (eQTL) of TSLP [43].