The fourth strongest association with cognitive impairment was a SNP upstream of the GRIN2B gene (rs3764030; 12p12; Padjusted = 9.4 × 10–8), which encodes the protein GluN2B, a receptor that is primarily expressed in the fronto-parieto-temporal cortex and is involved in learning and memory.[43] Genetic variations within GRIN2B have been associated with cognitive phenotypes.[44]. Here, GRIN2B is linked to Cognitive impairment.