CYP11B2 and essential hypertension: Essential hypertension (EH) is a kind of complex diseases and a major risk factor for diseases such as cardiovascular disease and kidney failure.[3–5] The renin–angiotensin–aldosterone system (RAAS) plays an important role in modulating blood pressure (BP) in EH by regulating sodium and intravascular volume homeostasis.[6,7] Aldosterone is a key component of the RAAS.[8,9] Aldosterone synthase, a member of the cytochrome P450 superfamily of enzymes, is encoded by CYP11B2, which is spread over 7 kb on chromosome 8q24.3, and contains 9 exons.