Previous studies have shown that gain-of-function mutations in SCN11A are been linked to painful peripheral neuropathy[5,35,36] and familial episodic pain.[4,37,38] In fact, Zhang et al[4] have identified gain-of-function mutations in SCN11A (Arg225Cys and Ala808Gly) that increased electrical activity and promoted action potential firing in dorsal root ganglion neurons in 2 Chinese families with episodic pain. Here, SCN11A is linked to peripheral neuropathy.