The median year of fracture diagnosis was 2007 (interquartile range 2004–2009), 67% of cases were men, 71% diagnosed with HIV infection before 1997, median age was 49 years, CD4 436 [293–592], nadir CD4 196 [82–287], 31% at AIDS-stage, 65% with VL <50 cp/ml and 49% exposed to tenofovir, 82% to PIs and 37% to efavirenz. The gene discussed is CD4; the disease is HIV infectious disease.