SIRT1 and colorectal cancer: Interestingly, previous reports from our laboratory have shown that resveratrol exerts its inhibitory effects in colorectal cancer through its activity on diverse subcellular targets, including NF-κB and Sirt1 and inhibition of epithelial-to-mesenchymal transition (EMT) markers with upregulation of intercellular junctions and E-cadherin and the downregulation of NF-κB and vimentin [26,30].