Our data reveal that resveratrol indeed suppresses CRC proliferation and invasion by up-regulation of Sirt1 activity, inhibition of NF-κB-mediated inflammatory pathway and suppression of focal adhesion kinase (FAK) activity, resulting in a loss of focal adhesion molecules, a planar surface of the CRC cells and an increase in apoptosis. The gene discussed is PTK2; the disease is colorectal carcinoma.