However, the resveratrol-induced expression of Sirt1 protein in the nuclei of HCT116 was significantly decreased by incubation with FAK-I and CytD (Figure 3C,D), indicating that FAK and cytoskeletal signaling proteins, at least in part, are some of the main target proteins of resveratrol during the resveratrol-induced anti-tumor effect in CRC cells. The gene discussed is PTK2; the disease is colorectal carcinoma.