SIRT1 and colorectal carcinoma: Indeed, in CRC cells, resveratrol-induced Sirt1 has a functional role in inhibiting activation of the NF-κB signaling pathway [26,30], wereby Sirt1 deacetylates the NF-κB-p65 subunit and thus attenuates NF-κB-mediated gene transcription and inflammation pathways [59].