It has been reported that PLK1 also interacts with other tumor suppressors such as CHK2 [59], BRCA1/2 [60,61], ATM [62] and ATR [63], BUB1B or BUBR1 [64,65], CYLD [66], REST [67], and TSC1/2 [68,69]. The gene discussed is PLK1; the disease is neoplasm.