Furthermore, several genetics studies have linked single nucleotide polymorphisms (SNPs) in RasGRP1 to human autoimmune disease (Plagnol et al., 2011; Qu et al., 2009), and low RasGRP1 levels have been detected in T lymphocytes from patients with Systemic Lupus Erythematosus (SLE) (Yasuda et al., 2007), and rheumatoid arthritis (RA) (Golinski et al., 2015). Here, RASGRP1 is linked to rheumatoid arthritis.