CXCL12 and neoplasm: In addition, a microfluidic model that includes the endothelium and perivascular matrix containing CXCL12 chemokines was developed to observe the transendothelial invasion of tumor aggregates and analyze the extravasation process of salivary gland adenoid cystic carcinoma (ACC) cells exposed to CXCL12 (Figure 5B) [61].