GATA6 and Alagille syndrome: Mutations in GATA6 cause PTA (Kodo et al., 2009) and haploinsufficiency of JAG1 (a Gata6 target detected in this study) causes Alagille syndrome, a congenital disorder associated with OFT and great vessels defects (Li et al., 1997; Oda et al., 1997).