It is therefore possible that in liver disease, in addition to clonal expansion of adaptive‐like CD49a+ liver‐resident NK cells, there is hepatic recruitment of newly generated CD49a + CXCR6+ NK cells, capable of releasing high levels of Th1 cytokines, induced by systemic inflammation in the peripheral blood including high levels of IL‐12/IL‐15. This evidence concerns the gene CXCR6 and liver disorder.