Of the three patients in our cohort with significant enrichment of hepatic CD49a+ NK cells, one had hepatocellular carcinoma, one had aggressive colorectal cancer with synchronous lesions and bi‐lobar liver metastases and the third had colorectal metastases extending to the resection margins, suggesting that high frequencies of CD49a+ NK cells are associated with more severe liver disease. The gene discussed is ITGA1; the disease is liver disorder.