TARDBP and cancer: Of the 28 miRNAs reported as hits in either LUSC or LUAD samples, 22 have previous literature exploring their roles in cancer (12 miRNAs are indicated as suppressors and 10 are reported as oncomiRs; see Tables S7 and S8); there was a trend toward tumor suppressor TDP-43-regulated miRNAs being down-regulated (hypergeometric test P-value for LUAD (4/4 vs. 40/85) and LUSC (7/9 vs. 40/85) respectively: 0.045 and 0.054), which suggested that TDP-43 is a tumor promoter.