In order to examine how TDP-43 might be involved in lung cancer via the miRNAs that it regulates, we designed an analysis pipeline that combined ProMISe (probabilistic miRNA-mRNA interaction signature) (Li et al., 2014), DESeq2 (Love et al., 2014), Fatiscan (Al-Shahrour et al., 2007a), and FatiGO (Al-Shahrour et al., 2007b). The gene discussed is TARDBP; the disease is lung cancer.