In addition, though previous studies have documented association of TDP-43 expression with cancer, the underlying mechanisms of this association remain to be elucidated (Fang et al., 2011; Postel-Vinay et al., 2012; Teittinen et al., 2012;Campos-Melo et al., 2014; Park et al, 2013). The gene discussed is TARDBP; the disease is cancer.