A multivariate model including all clinicopathological features identified muscle invasion (pT2 and 3; HR = 5.4, 95% CI = 2.24–13.03; p < 0.001) but not cancer cell FES expression (HR = 1.3, 95% CI = 0.52–2.97; p = 0.617) as an independent predictor of subsequent metastasis. This evidence concerns the gene FES and cancer.