Including the Dalian Han people as the research population, this study performed case-control research to (1) detect the expression of antioxidase encoding genes (GSTM1 and GSTT1), (2) explore the relationship between gene deletion individuals and their susceptibility to COPD, and (3) investigate the relationship between antioxidant capacity, genes, and the presence of COPD. Here, GSTM1 is linked to chronic obstructive pulmonary disease.