SLC12A3 and kidney disorder: Exosomal RNAs, miRNAs, and proteins can mirror gene expression changes in kidney diseases (70, 76) promising to be effective and non-invasive biomarkers for renal disease and may be used as surrogate markers of RAAS activation, affecting expression of the epithelial sodium channel (ENaC) (OMIM: 600228), the thiazide-sensitive sodium-chloride-cotransporter (NCC) (OMIM: 600968) (77, 78) among others.