Patients diagnosed with Gordon syndrome had a fourfold increase in the abundance of NCC in urinary exosomes when compared to controls (90); a recent publication in patients under exogenous mineralocorticoid (fludrocortisone) administration showed a reduction of 48% in the phosphorylated NCC (pNCC)/NCC ratio along with a rapid increase in the abundance of NCC and pNCC in urinary exosomes, possibly through the WNK pathway (77). Here, SLC12A3 is linked to Gordon syndrome.