KCNH2 and torsades de pointes: Whereas current in vitro methods for predicting TdP risk focus almost exclusively on block of Kv11.1 (i.e., the hERG channel), an approach that is often inadequate, CiPA intends to both assess how drugs block multiple ion channels and to combine these measurements with recordings in hiPSC-CMs and mechanistic simulations (Sager et al., 2014; Fermini et al., 2016).