Compared with the WT mice, IRAK-M−/− mice demonstrated more obvious lung inflammation evidenced by more inflammatory cells infiltrated in the airways (BAL total inflammatory cells, neutrophils, and lymphocytes) (Figures 1(a), 1(b), 1(c), and 1(d)) and deposited around peribronchus and vascular (Figure 1(e)). The gene discussed is IRAK3; the disease is inflammatory response.