There was a significant decrease in the level of anti-inflammatory cytokine IL-27, not IL-10, in lung homogenates from IRAK-M KO mice relative to their WT counterparts in response to subacute CS injury, reflecting the nonspecific inhibition of immune activation under subacute CS stimulation in absence of IRAK-M. The gene discussed is IRAK3; the disease is Cowden syndrome 1.