PLA2G7 and early-onset autosomal dominant Alzheimer disease: Moreover, previous studies have indicated that high Lp-PLA2 activity is a risk factor for dementia, independent of cardiovascular disease and inflammatory factors17,18, and a meta-analysis of more than 79,000 subjects showed that higher Lp-PLA2 mass or activity increases the risk of stroke, coronary heart disease, and vascular mortality which are associated with the development of Alzheimer’s disease (AD) and dementia19.