Moreover, previous studies have indicated that high Lp-PLA2 activity is a risk factor for dementia, independent of cardiovascular disease and inflammatory factors17,18, and a meta-analysis of more than 79,000 subjects showed that higher Lp-PLA2 mass or activity increases the risk of stroke, coronary heart disease, and vascular mortality which are associated with the development of Alzheimer’s disease (AD) and dementia19. This evidence concerns the gene PLA2G7 and Alzheimer disease.