CD4 and infection: Although previous studies have suggested that EBOV GP may shield MHC detection (68, 69), we note that these studies were performed in transduced and transfected DCs where GP is highly expressed; as CD4+ T cells are refractory to infection and a relatively low MOI of 1.0 was used for the majority of these studies, it is highly improbable that the decrease in CD3 expression is due to shielding effects.