For examples, mutations in clathrin and several of its associated proteins and adaptors (EPS15, HIP1, CALM, endophilin and β-arrestin 1) were identified via systematic characterization of somatic mutations in breast, renal and lung cancers [26, 27], which is the main function in term GO:2000370 (positive regulation of clathrin-dependent endocytosis). Here, EPS15 is linked to lung cancer.