FOXM1 and breast carcinoma: To further understand the biological meaning of GPU-ARACNE inferred gene regulatory network, we focused on breast cancer regulatory network, specifically FoxM1 (Forkhead box protein M1) transcriptional network (regulon) as FoxM1 was predicted to have the largest regulon by GPU-ARACNE (Fig. 6), supporting previous findings that it was highly activated in breast cancer tumors [26, 27].