PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Among the rare variants typed with TaqMan, rs143392071 (PNPLA3, Tyr220Cys) and rs756998920 (MTTP, Val42Ile) showed a significant association with ultrasonographic diagnosis of NAFLD (OR = 3.52, 95% CI = 1.38–8.95, P = 0.008 for rs143392071 and OR = 0.03, 95% CI = 0.002–0.57, P = 0.019 for rs756998920) (Table 2).