IDH2 and acute myeloid leukemia: For instance, glioblastoma or acute myeloid leukemia (AML) tumors that harbor IDH1/ IDH2 mutations are particularly dependent on the function of the GAC isoform for the anaplerotic replenishment of αKG, which is the source material used to generate the onco-metabolite 2-HG by these mutant enzymes [22–25].