PRCC-TFE3 renal cell carcinoma (RCC) is one of the most common types of Xp11.2 translocation renal cell carcinoma (tRCC), of which the diagnosis mainly relies on reverse transcription-polymerase chain reaction (RT-PCR) or chromosomal analysis in fresh frozen samples. This evidence concerns the gene PRCC and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.