Xp11.2 translocation renal cell carcinoma (tRCC), a rare subtype of renal cell carcinoma (RCC), result from gene fusions involving the TFE3 transcription factor gene[1], and it is included into the MiT family tRCCs in the recently published World Health Organization (WHO) classification of tumors of the urinary system[2]. This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.