FCGR2A and infection: Our data showed that 2H5-A14 can mediate immune effector cells to kill HBV-infected cells in vitro via ADCC and ADCP, although more evdience is needed, it is conceivable to speculate that the clearance of cccDNA-carrying infected cells or decrease their in vivo half-lives by Fc-dependent effector functions via FcγR engagement, including cytotolytic and/or noncytolytic mechanisms, may have contributed to the anti-HBV effect of 2H5-A14 in a manner beyond Fab-mediated blockage of new infections.