MAPT and Alzheimer disease: Further support for this interpretation stems from recent data showing that JQ1 mediates anti-inflammatory actions in several disease models.43, 44, 45 Of note, JQ1 was also found to decrease the inflammation and Tau phosphorylation in an 3 × TG mice, another animal model for AD.24 It is in this context important to mention that JQ1 may affect other processes than chromatin plasticity and gene expression.