However, the effect of JQ1 and other BET/BRD inhibitors in the adult brain is not well defined and the few data that exist does not allow for a defined conclusion.20, 21, 22, 23, 24 As such, a detailed investigation on the effects of JQ1 on memory function and synaptic plasticity in the context of neurodegenerative diseases is missing. This evidence concerns the gene DNER and neurodegenerative disease.