APOE and Alzheimer disease: Hence, APOE‐ε4 is directly associated with mitochondrial toxicity and beta‐amyloid deposition contributing to Alzheimer's Disease (AD) in a dose‐dependent manner (ε4 carrier, 5‐fold; ε4/ε4: 20‐fold) (Blennow, Mattsson, Schöll, Hansson, & Zetterberg, 2015; Hauser & Ryan, 2013).