The analysis of obese patients in our sample could confirm that KCTD15 and TFAP2B variants may be related to obesity risk, a finding that has also been suggested by a number of GWAS and replication studies (Albuquerque et al., 2014; Bauer et al., 2009; Lv et al., 2015; Willer et al., 2009). This evidence concerns the gene TFAP2B and obesity due to melanocortin 4 receptor deficiency.