In this regard, several loci in or near KCTD15 have repeatedly been associated with obesity in a number of GWAS and replication studies (Mei et al., 2012; Paternoster et al., 2011; Thorleifsson et al., 2009; Willer et al., 2009). The gene discussed is KCTD15; the disease is obesity due to melanocortin 4 receptor deficiency.