BDNF and obesity due to melanocortin 4 receptor deficiency: It has been demonstrated that dietary supplementation with the antioxidant curcumin reduces oxidative stress (Martínez‐Morúa et al., 2013), and reduces the brain damage by increasing the brain derived neurotrophic factor (BDNF) levels in obesity and diabetes mice (Franco‐Robles et al., 2014).