IL4 and Shock: Myeloid-restricted SOCS3 deletion (Socs3Lyz2cre) resulted in resistance to LPS-induced endotoxic shock and observed striking bias toward M2 macrophages in Socs3Lyz2cre mice, enhanced regulatory T (Treg) cell recruitment by Socs3Lyz2cre cells coincided with enhanced interleukin-4 (IL-4) plus IL-13-induced STAT6 phosphorylation in Socs3Lyz2cre macrophages.