PPARA and breast carcinoma: Although fenofibrate promotes breast cancer cell apoptosis via NFκB-mediated activation of caspase-3 and expression of Bad, which is independent of PPARα activity [27], clofibrate or wyeth14,643 induces hepatocarcinoma HepG2 cell apoptosis [29] and inhibits tumor progression [11] in a PPARα-dependent manner.