SMO and chronic myelogenous leukemia, BCR-ABL1 positive: Meanwhile, in non-solid neoplasms such as chronic myeloid leukemia (CML), the overexpression of SMO has been associated with a loss of expression of miR-136 in marrow-derived CD34+ cells, while overexpression of miR-326 decreases the expression of SMO, diminishing cell proliferation and increasing the apoptotic activity of CD34+ CML cells.