GPT and heart failure: 3,744 participants without clinical heart failure showed that AST and ALT levels were significantly associated with an increased risk of incidental AF (ALT hazard ratio 1.19, 95% CI 1.07–1.32, p = 0.002; AST hazard ratio 1.12, 95% CI 1.01–1.24, p = 0.03) in the Framingham Heart Study Original and Offspring cohorts.