Also, it was observed that reduction of miR-125b increased the chemosensitivity of breast cancer cells to 5-FU by targeting E2F3 and high miR-125b expression was correlated with poor clinical response of breast cancer patients to chemotherapy, suggesting that circulating miR-125b levels had potential of being used as a therapeutic target for reversing clinical chemoresistance [63]. Here, E2F3 is linked to breast cancer.