Virtually half of MM tumors are hyperdiploid, the remaining ones are frequently associated with the constitutive activation of CCND1 (11q13), CCND3 (6p21), MAF (16q23), MAFB (20q11), or FGFR3/MMSET (4p16.3) genes, as a result of chromosomal translocations involving the IGH locus on chromosome 14q32. Here, NSD2 is linked to Miyoshi myopathy.