GAS5 and mantle cell lymphoma: Specifically, Mourtada-Maarabouni and Williams [66] used RNA interference in MCL cell lines to downregulate the lncRNA Growth Arrest Specific (GAS5), a cell-cycle arrest and apoptosis-related lncRNA with tumor suppressor activity [67–71], based on the fact that it is a known effector of the mTOR pathway in normal and transformed T lymphocytes [72, 73].