BALR-6 showed some similarities with BALR-2 as silencing of BALR-6 in human B-ALL cell lines led to decreased cell proliferation and increased apoptosis, whereas overexpression of BALR-6 isoforms in both human and murine cell lines induced increased growth and a partial resistance to prednisolone treatment. This evidence concerns the gene CDK6-AS1 and precursor B-cell acute lymphoblastic leukemia.