The thrombotic disease or inflammation progress-related protein PF4 and sFRP1, a member of the Wnt/fz signal-transduction pathway, related to cardiac hypertrophy and myocardial repair after MI, are particularly important in severe CAD owing to the significant up-regulation in triple-vessel disease with/without left main stenosis. This evidence concerns the gene SFRP1 and myocardial infarction.