Germline mutations in one of the breast cancer susceptibility genes, BRCA1 (MIN #113705) or BRCA2 (MIN#600185), are the major and most widely known risk factors for breast and/or ovarian cancer (BOC) hereditary syndrome (HBOC) [1, 2], although they are present in about 40% of cases with strong family BOC background. The gene discussed is BRCA2; the disease is ovarian cancer.