The network analyses in the current study also implicate miRNAs of miR-638, miR-5787, miR-8075, miR-6869-5p and miR-548c-5p are aberrantly expressed in the serum exosomes of patients with CRC, and these miRNAs might modulate the glucose metabolism in CRC by targeting HIF-1α, VEGF, PGK1, MAPK and other molecules involved in glucose metabolism. Here, PGK1 is linked to colorectal carcinoma.