These results showed that the decrease in the metastasis of melanoma cells may result from low migratory ability (Figure 1B) because DMGF could reduce the formation of lamellipodia (Figure 7A) by interfering with F-actin polymerization by lowering the phosphorylation of CREB to suppress the expression of Cdc42/Rac pathway associated genes (Figures 7 and 8). This evidence concerns the gene CREB1 and melanoma.