LOX and neoplasm: RT significantly increased the expression of LOX in both the cytoplasm (P < 0.001) and nucleus (P = 0.010) in normal mucosa whereas no significant difference was found either in primary tumours (P = 0.543 for the cytoplasm, and P = 0.873 for the nucleus) or in lymph node metastases (P = 0.310 for the cytoplasm, and P = 0.960 for the nucleus) (Supplementary Figure 2).