In contrast, only three DMPs—cg00574958, cg07839457 and cg20399616—, annotated to genes CPT1A, NLRC5 and BCAT1, respectively, were significantly differentially methylated in those with obesity compared with those without (Table 2 and Fig. 1). Here, NLRC5 is linked to obesity due to melanocortin 4 receptor deficiency.