DMP cg07839457 located 1.5 kb upstream of the transcription start site (TSS) of NLRC5 was found in our study to be hyper-methylated for higher BMI and WC, and 7.1% hyper-methylated in those with obesity compared with those without (Tables 2 and 3). The gene discussed is NLRC5; the disease is obesity due to melanocortin 4 receptor deficiency.