CPT1A and obesity due to melanocortin 4 receptor deficiency: The DMP annotated to gene CPT1A, which was significantly hypo-methylated in individuals with obesity, was also significantly hypo-methylated in individuals with abdominal obesity compared with those without (Table 3 and Additional file 1: Figure S8), with similar odds (OR = 0.84, 95% CI 0.79–0.90) for abdominal obesity as for obesity (Table 4).