TGFB1 and neoplasm: The phenomenon of epithelial to mesenchymal transition, typical of solid tumors and linked to metastatization ability, is another evidence of mesenchymal contribution to tumor escape: malignant epithelial cells modify their transcriptional programme losing cell–cell attachments and acquiring mesenchymal-like features and motility, through deregulation of molecular pathways that include TGFβ, Wnt, Notch, hedgehog, and tyrosine kinase receptors.