Considering that MOB1(D63V) and MOB1(K104E/K105E) still bind to NDR1/2 (Fig. 3c and Supplementary Fig. 6) and that MOB1(K104E/K105E) is phosphorylated on Thr12 and Thr35 in MCF-7 cells comparable to wild-type MOB1 (Supplementary Fig. 15), we are therefore tempted to conclude that MOB1 binding to NDR1/2 can be sufficient to at least in part suppress cancer-related features in human cancer cells grown in 2D. Here, SGMS1 is linked to cancer.