ZNF516 and colorectal cancer: Significantly, ZNF516 has been shown to experience frequent copy number loss in colorectal cancer that is associated with chromosomal instability and aneuploidy onset at adenoma–carcinoma transition25, and hypermethylation of ZNF516 promoter has been detected in cervical neoplasia that is suggested as a better biomarker26, underscoring the importance of this transcriptional regulator itself in tumorigenesis.