Intriguingly, it has been documented that amplifications in the EGFR gene are restricted to regions of the regulatory sequence in the 5′-end of intron 1 and associated with EGFR expression in epithelial breast tumors14, suggesting that transcriptional regulation of EGFR might be pathologically relevant in breast cancer carcinogenesis by contributing to EGFR overexpression. This evidence concerns the gene EGFR and breast carcinoma.