The identification of EGFR as a target of the ZNF516–CtBP/LSD1/CoREST complex and the well-documented role of EGFR in the development and progression of of various malignancies3–5 suggest that the ZNF516–CtBP/LSD1/CoREST complex may also function in breast cancer growth and metastasis. This evidence concerns the gene CTBP1 and breast cancer.