cPLA2α, an AA-specific intracellular PLA2 that is activated by Ca2+ and phosphorylation following diverse stimuli62,63, mobilizes a large pool of colonic PGE2, which is protective against acute injury but accelerates chronic colitis and cancer, most likely by acting on distinct PGE2 receptors spatiotemporally expressed in different cells6–8,24,25. The gene discussed is PLA2G2A; the disease is cancer.