Lastly, given that sPLA2-III, an atypical sPLA2, is insensitive to classical sPLA2 inhibitors and that no protein structurally homologous to sPLA2-III is encoded in the human genome, a new agent that specifically inhibits this unique sPLA2 may be useful for the treatment of patients with IBD and colorectal cancer. This evidence concerns the gene PLA2G10 and inflammatory bowel disease.