The proposed connection of sPLA2-III with colorectal cancer has arisen from the findings that overexpression of sPLA2-III in colon cancer cells enhances proliferation both in culture and in nude mice34, that higher expression of sPLA2-III is significantly correlated with more aggressive metastasis and poorer prognosis in patients with colorectal cancer35, and that human PLA2G3 polymorphisms are significantly associated with a higher risk of colon cancer36. This evidence concerns the gene PLA2G3 and colonic neoplasm.