PLA2G3 and colonic neoplasm: To assess the role of sPLA2-III in colonic cancer, we applied a colon carcinogenesis model induced by azoxymethane (AOM), a procarcinogen that – upon metabolic activation in the liver and distal colon – induces the formation of O6-methyl-guanine39, in Pla2g3−/− mice and also littermate Pla2g3+/+ mice for comparison.