For instance, the reduced expression of Pla2g2d corroborates the decrease of tumor-promoting M2-like macrophages (Fig. 2g)58, the reduced expression of Plcg1 and Plcg2 could explain the decreased growth factor signaling59, and the altered expression of several lipogenic, lipolytic and β-oxidation genes might reflect cancer-associated metabolic reprogramming60, in AOM-treated Pla2g3−/− mice relative to Pla2g3+/+ mice. Here, PLCG2 is linked to infectious otitis media.