PLA2G2A and neoplasm: Group IIA secreted PLA2 (sPLA2-IIA), an intestinal Paneth cell-derived sPLA2 also known to be a genetic modifier for tumor multiplicity in mice27, reduces susceptibility to intestinal tumorigenesis possibly by altering the differentiation and function of intestinal stem cells, by mobilization of eicosanoids, or by other mechanisms28.