2016; Jablonski et al. 2016; Zhang et al. 2016). However, no such effect was found, as both WT and miR155−/− mice displayed similar gene expression profiles with respect to adipose tissue macrophage polarization and inflammatory markers (MCP‐1 & TNF‐α), JNK activation, and impaired glucose metabolism and insulin resistance. Interestingly, these outcomes presented themselves even though miR155−/− HFD mice accumulated less visceral adipose tissue, specifically with respect to the epididymal fat pad, compared to WT HFD mice. Here, MAPK8 is linked to Insulin resistance.