IGF1 and Hyperglycemia: The GH-IGF system has evolved to provide a distinct advantage to the organism, with IGF-1 augmenting the growth-promoting actions of GH while countering its potentially deleterious effects of hyperglycemia and lipid store depletion (5); the anabolic actions of IGF-1 are synergistic to those of GH, whereas its metabolic actions are antagonistic.