Second, at present, we know little about the detailed mechanism by which how lnc-IGFBP4–1 regulate or reprogram the cellular energy metabolism to promote cancerous cells proliferate, invade and metastasize, our future work will focus on the mechanisms of how lnc-IGFBP4–1 serves as a tumor promoter gene involved in LC development by regulating metabolic programming. This evidence concerns the gene IGFBP4 and neoplasm.