First, we found that the average level of lnc-IGFBP4–1 in lung cancer tissues was significantly higher than those in corresponding non-tumor tissues and lnc-IGFBP4–1 expression was significantly correlated with TNM stage and lymph node metastasis, indicative of lncRNA-IGFBP4–1 as a key regulator in LC progression and as a potential novel biomarker for LC. This evidence concerns the gene IGFBP4 and laryngotracheoesophageal cleft.