IGFBP4 and neoplasm: As shown in Fig. 5, the tumor volume in the overexpressed lnc-IGFBP4–1treatment group was significantly increase compared to that in the control group, and tumor volume was 636 ± 64.1 mm3, which was significantly bigger than that in control group (441 ± 58.5 mm3) on the day 24 (P < 0.05).